GREENVILLE, N.C.—Skip Holtz followed his biggest coaching victory at East Carolina with an even more impressive one.

Jonathan Williams had two short touchdown runs, quarterback Patrick Pinkney was nearly perfect and the Pirates routed No. 8 West Virginia 24-3 on Saturday for their third straight win over a ranked team.

Pinkney was 22-of-28 for 236 yards with a touchdown for East Carolina (2-0), which opened the season with a last-minute upset of then-No. 17 Virginia Tech.

This one was decided much earlier. The Pirates never trailed, kept Pat White in check, ...

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