FOXBOROUGH, Mass.—The New England Patriots have come back from injuries before, winning three Super Bowls and reaching a fourth despite losing Rodney Harrison, Richard Seymour, Junior Seau and Drew Bledsoe.

Now they will try to do it without Tom Brady.

The 2007 NFL Most Valuable Player will miss the entire ’08 season with a left knee injury that needs surgery, the team said Monday. That leaves the Patriots without one of the game’s great quarterbacks and severely damages their hopes of a return trip to the Super Bowl.

Coach Bill Belichick would not say what ...

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