LOUISVILLE, Ky.—Paul Azinger had pairings in his pocket and butterflies in his stomach.

As the last of his American players headed to the 10th tee for the final practice session Thursday at the Ryder Cup, Azinger acknowledged some nerves for the first time all week at Valhalla.

It was different from being a player. He felt more like a parent sending his child off to college.

Azinger has done all he can to stop Europe’s recent dominance in the Ryder Cup. He overhauled the qualifying process to field the best team. He set the course up just like he wanted, wit...

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