GUADALAJARA, Mexico—Angela Stanford shot a 6-under 66 on Friday in the second round of the Lorena Ochoa Invitational to take a two-stroke lead over LPGA Championship winner Yani Tseng.

Stanford had a 10-under 134 total on the Guadalajara Country Club course. Tseng, No. 2 in the world behind Ochoa, shot her second straight 68. Ochoa followed her opening 73 with a 71 on her home course, leaving her 10 strokes back.

Meena Lee (69) was 6 under, and Karen Stupples (71) was 5 under. Annika Sorenstam (72), leaving the tour at the end of the season, was 4 under in group that in...

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