AMES, Iowa—Chase Daniel threw for 328 yards and two touchdowns and No. 12 Missouri clinched the Big 12 North and a spot in the conference title game by crushing Iowa State 52-20 Saturday night.

The Tigers’ opponent is still anyone’s guess, with Oklahoma, Texas and Texas Tech all still in the mix for the South title.

Swirling winds and temperatures in the high 20s had little effect on Daniel and Missouri’s high-flying offense. Daniel went 32-of-40 and completed his first 16 passes as the Tigers (9-2, 5-2 Big 12) jumped out to a 31-7 halftime lead.

Derrick Was...

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