MAR DEL PLATA, Argentina—Feliciano Lopez and Fernando Verdasco sent a chill through Argentine tennis Saturday, winning their doubles match to give Spain a 2-1 lead in the Davis Cup final.

Lopez and Verdasco defeated David Nalbandian and Agustin Calleri 5-7, 7-5, 7-6 (5), 6-3, boosting Spain’s hopes of winning the best-of-five championship on the road despite the absence of an ailing Rafael Nadal.

Spain could be in good position for its third Davis Cup crown if Argentina’s leading player, Juan Martin del Potro, cannot play reverse singles today because of a leg injury. <...

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