MONACO—The Tour de France is ready for another edition with Lance Armstrong, and Saturday’s opening stage may show whether he’s ready to challenge for another title.

Armstrong’s 37-year-old legs will be tested immediately when the three-week race begins with a 9.6-mile time trial. The stage will be run along the hilly streets and hairpin turns of Monaco, a Mediterranean principality better known for Formula One than for huffing two-wheelers.

The ride will likely offer an early shakeout of potential contenders who want to at least hold their own in the race against the c...

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