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NEW YORK—Wall Street ended a depressing week with another big loss on Friday, with the Dow Jones industrials falling more than 100 points amid ever-escalating worries about high oil prices and fallout from the credit crisis. The major indexes are all down more than 3 percent for the week.

The Dow has fallen nearly 460 points in the last two sessions and reached its lowest point since September 2006.

Investors again contended Friday with a seemingly relentless stream of troubling news about the financial sector. Moody’s Investors Service said it is reviewing investment b...