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HOUSTON—Police have few leads in the disappearance of a Haworth, Okla., man who attends Rice University.

Matthew Wilson, 20, was reported missing Tuesday by his roommate, said Rice University Police Chief Bill Taylor.

“We have absolutely nothing at this point. It’s just like ‘poof’, he evaporated,” Taylor said.

He said investigators do not suspect foul play.

Wilson, a junior computer science major, failed to take his final exams, which his friends and family say is out of character for him.

“He’s a serious student. He has a pretty sub...