TORONTO-Chris Sale struck out 13 over eight shutout innings, Mookie Betts hit a three-run double in the 10th and the Boston Red Sox beat the struggling Toronto Blue Jays 4-1 on Thursday.
At 3-12, Toronto is off to the worst start in team history and has lost its first five series for the first time.
Sandy Leon drew a one-out walk from Jason Grilli (0-2), Brock Holt singled to stop an 0-for-12 slide, Andrew Benintendi walked with two outs, and Betts pulled a 2-0 fastball down the left-field line.
Mitch Moreland hit a two-out double in the ninth off Roberto Osuna and scored on Xander Bogaerts' single, but Kendrys Morales homered against Craig Kimbrel (1-0) leading off the bottom half.
RAYS 8, TIGERS 1
ST. PETERSBURG, Fla.-Steven Souza Jr. came within a single of hitting for the cycle, and Erasmo Ramirez (2-0), Chase Whitley and Tommy Hunter combined on a five-hitter as Tampa Bay completed a three-game sweep.
Souza doubled in the first, hit a two-run triple in the second and added a solo homer in the eighth.
In the rotation because Jake Odorizzi strained his left hamstring, Ramirez allowed one run and two hits in five innings with five strikeouts and no walks.
Daniel Norris (1-1) gave up five runs and eight hits over 4 2/3 innings.
INDIANS 6, TWINS 2
MINNEAPOLIS-Trevor Bauer (1-2) struck out seven in 6 1/3 innings, giving up two runs, three hits and three walks, and Carlos Santana had two doubles and two RBIs.
Ervin Santana gave up one run, four hits and three walks over six innings for the Twins, who are 1-5 in a 10-game homestand.
Carlos Santana delivered another RBI double in the seventh inning, and Tyler Duffey (0-1) and Taylor Rogers each walked in a run with the bases loaded.
PHILLIES 6, METS 4
NEW YORK-Maikel Franco homered and doubled while breaking a career-worst 0-for-22 hitless streak, and Philadelphia capitalized on an error by untested first baseman Jay Bruce.
Mets closer Jeurys Familia struck out two and walked two in a hitless ninth inning of his season debut after serving a 15-game suspension for violating Major League Baseball's domestic violence policy.
Philadelphia took two of three at Citi Field after losing six straight series to the Mets. New York made seven errors in the set.
Aaron Nola (2-0) labored through five innings, and Hector Neris earned his first save this season. Noah Syndergaard (1-1) struck out 10 in seven
innings.
New York slugger Yoenis Cespedes limped off in the fifth inning with a left hamstring cramp. The Mets already were minus injured first baseman Lucas Duda, catcher Travis d'Arnaud and infielder Wilmer Flores.
ORIOLES 2, REDS 1
CINCINNATI-J.J. Hardy singled home the tiebreaking run off Blake Wood (0-2) in the 10th inning, and the Orioles took two of three in the series, leaving them 8-4 in interleague play against the Reds. Three pitchers limited Cincinnati to two hits for the second night in a row.
Darren O'Day (1-1) fanned two of the three batters he faced in the ninth. Brad Brach retired the side in the 10th for his second straight save, filling in while closer Zach Britton recovers from a sore forearm.