DENVER - Eddy Pineiro kicked a 53-yard field goal as time expired, giving the Chicago Bears a wild 16-14 win over the Broncos and their former defensive coordinator Vic Fangio, whose gutsy 2-point call 31 seconds earlier had given Denver the lead.
The Broncos (0-2) thought time had expired when Mitchell Trubisky stepped up and threw a 25-yard pass to Allen Robinson on fourth-and-15 from his 40-yard line. Robinson was tackled at the Denver 35 by Chris Harris Jr.
The clock showed all zeroes and both teams milled around on the field not knowing whether to celebrate a win or lament a loss. Then referee Adrian Hill announced there was 1 second remaining and Chicago was using its last timeout.
Pineiro's winner sent the Bears (1-1) streaming back onto the field in celebration of a victory that seemed so unlikely after they'd surrendered the lead moments earlier.
Seahawks 28, Steelers 26
Russell Wilson threw for three touchdowns, including a 28-yard rainbow to DK Metcalf midway through the fourth quarter.
The Steelers lost starting quarterback Ben Roethlisberger to a right elbow injury late in the first half and fell to 0-2 for the first time since 2013 despite solid play from backup Mason Rudolph, who threw a pair of second-half touchdown passes to Vance McDonald.
Roethlisberger began flexing his right arm after an incompletion late in the second quarter. He stayed in to finish the drive before jogging to the locker room. When the 37-year-old QB emerged for the second half, he was wearing a white cap while Rudolph, taken in the third round of the 2018 draft, took the first meaningful snaps of his career.
Rudolph completed 12 of 19 passes for 112 yards, the two scores and an interception, but couldn't quite keep pace with Wilson and the Seahawks (2-0).
Wilson was 29 of 35 for 300 yards and the three TDs, becoming the fifth-fastest quarterback in league history to reach 200 career touchdown passes (114 games). Wilson also ran four times for 24 yards, most of it coming on Seattle's final drive as the Seahawks protected a two-point lead.
A week after escaping Cincinnati with a one-point win, a game in which coach Pete Carroll said his team wasn't particularly crisp, the Seahawks took advantage of a series of mental mistakes by the Steelers (0-2) to win in Pittsburgh for the first time in 20 years.
Chiefs 28, Raiders 10
OAKLAND, Calif. - Patrick Mahomes bounced back from the first scoreless opening quarter of his career in the regular season by throwing four touchdown passes in a near perfect second period.
The Raiders (1-1) held Mahomes in check for the opening 15 minutes before he carved up an overmatched defense with big play after big play in the second quarter for the Chiefs (2-0).
Mahomes didn't take long to strike, finding Demarcus Robinson open on a blown coverage for a 44-yard touchdown pass on the first play in the second quarter. He didn't slow down from there.
Mahomes finished 30 for 44 for 443 yards. Robinson had six catches for 172 yards and two scores and Kelce had seven catches for 107 yards and a TD to give the Chiefs their ninth win in the past 10 meetings in this long-time rivalry.
Colts 19, Titans 17
NASHVILLE, Tenn. - Jacoby Brissett became the latest Indianapolis quarterback to top Tennessee, throwing a 4-yard touchdown pass to T.Y. Hilton with 4:38 left. Brissett had come up empty for Indianapolis against Tennessee, losing both games he started against the Titans in 2017. After Andrew Luck retired with a perfect 11-0 record against the Titans, Brissett picked up right where Luck left off. He passed for 146 yards and three TDs.
The Colts (1-1) also sacked Marcus Mariota four times on a day when Adam Vinatieri, the NFL's oldest player and career scoring leader but in an early-season slump, missed two extra points. It was Indianapolis' 14th win in its last 16 games against Tennessee overall.
The Titans (1-1) missed their chance for payback against Indianapolis after losing the 2018 regular-season finale, along with a playoff berth on the line for the winner. They haven't started 2-0 since 2008 when they won their first 10 games and last won the AFC South.
Ravens 23, Cardinals 17
BALTIMORE - Lamar Jackson kept the Cardinals guessing all afternoon, supplementing an effective passing attack with more than an occasional jaunt out of the pocket. Jackson threw for 272 yards and two touchdowns and ran for 120 yards in a showdown between two of the league's most exciting young quarterbacks.
After achieving a perfect passer rating and throwing five TD passes in a season-opening 59-10 rout of Miami, Jackson wasn't quite as sharp through the air but far more effective with his legs. He ran 16 times (including two kneel-downs at the end), juking and twisting past defenders for key gains - especially when the Cardinals were dropping back in passing situations.
The 2016 Heisman Trophy winner outdid the 2018 Heisman winner, Arizona rookie quarterback Kyler Murray, who went 25 for 40 for 349 yards but fell short of carrying the Cardinals to a second straight fourth-quarter comeback.
Murray guided Arizona (0-1-1) on a four-play, 79-yard touchdown drive to make it 20-17 with 12:52 remaining. One week earlier, the former Oklahoma standout erased an 18-point deficit to salvage a tie against Detroit.
Bills 28, Giants 14
EAST RUTHERFORD, N.J. - Somewhat maligned Josh Allen ran for a touchdown, threw for another, and the Bills claimed the bragging rights of New York.
Buffalo has its first 2-0 start since 2014 and only the third in 11 mostly fruitless years.
Devin Singletary scored on a 14-yard run and Frank Gore iced the game with a 1-yard plunge into the end zone with 5:53 to play as the Bills completed the New York/New Jersey sweep at MetLife Stadium. They beat the Jets last weekend.
Allen finished 19 of 30 for 253 yards in becoming Buffalo's first quarterback to pass for 200 or more yards in seven straight games since Hall of Famer Jim Kelly in 1992. His touchdown pass covered 14 yards to Isaiah McKenzie and his TD run was 6 yards.
Giants coach Pat Shurmur gave Buffalo bulletin-board material earlier in the week when he said he felt Allen had the potential to be an NFL starter coming out of the 2018 draft. The Bills felt it a slight for the No.7 overall pick and posted it.
Allen, who had no turnovers after making four last week, played like a quarterback with something to prove.
Saquon Barkley ran for 107 yards and a game-opening 27-yard touchdown run, but the Giants went to 0-2 for their sixth such start since 2013.
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Patriots 43, Dolphins 0
MIAMI GARDENS, Fla. - Antonio Brown caught a 20-yard touchdown pass in his debut for the Patriots, and they scored twice on interception returns in a two-minute fourth-quarter span.
Brown also made an 18-yard catch on his first play for the Patriots (2-0), who signed him Monday. He finished with 56 yards on four receptions, all in the first half.
The NFL allowed the four-time All-Pro receiver to play despite a civil lawsuit filed Tuesday by his former trainer accusing him of sexually assaulting her on three occasions.
New England's defense outscored Miami (0-2) with interception returns for touchdowns of 54 yards by Stephon Gilmore and 69 yards by Jamie Collins Sr. The Patriots totaled seven sacks and four interceptions and earned their most lopsided win in the 108-game history of the series.
49ers 41, Bengals 17
CINCINNATI - Jimmy Garoppolo tied his career high with three touchdown passes and the 49ers completed a sweet and satisfying week in the Buckeye State.
Rather than return to the West Coast after their opening 31-17 win in Tampa Bay, the 49ers headed to Youngstown, Ohio, where they worked out on a soccer field, enjoyed a local ice cream shop and rested at a Holiday Inn. Then they started their trek west with a resounding and notable win.
The 49ers improved to 2-0 for the first time since 2012. They've opened the season with back-to-back road wins for the first time since 1989, when Joe Montana's crew was coming off its second Super Bowl win over the Bengals.
The Niners piled up 573 total yards, their highest total in seven years. They've topped 30 points in each of their first two games for the first time since 1998. The 41 points were the most allowed by the Bengals (0-2) in a home opener.
Packers 21, Vikings 16
GREEN BAY, Wis. - Aaron Rodgers threw two early touchdowns on a day when the Packers honored late Hall of Famer Bart Starr at halftime.
Rodgers put on quite a show - particularly early. Rodgers completed nine of his first 10 passes for 134 yards and two touchdowns and had a perfect 158.3 rating through the first quarter. He finished 22 of 34 for 209 yards.
The Packers improved to 2-0 under new coach Matt LaFleur after opening the NFL's 100th season with a victory at rival Chicago. They also beat the Vikings (1-1) for the fifth time in the past seven games at Lambeau Field.
Kevin King intercepted Kirk Cousins late in the end zone to preserve the win.
Minnesota's Dalvin Cook had a career-high 154 yards and a touchdown on 20 carries. It was the third-year back's second consecutive game with over 100 yards rushing.
Lions 13, Chargers 10
DETROIT - Matthew Stafford threw a go-ahead, 31-yard touchdown pass to Kenny Golladay midway through the fourth quarter and Darius Slay made an interception in the end zone with 1:03 left.
Detroit (1-0-1) overcame Stafford's two interceptions, Slay giving up a lot of receptions and Matt Prater missing an extra point and a field goal.
The Chargers (1-1) were in a position to attempt a 45-yard field goal to tie the game, but Philip Rivers tried to force a pass to Keenan Allen and Slay picked it off.
Stafford was 22 of 30 for 245 yards with two TDs and two interceptions. Rivers was 21 of 36 for 293 yards and an interception.