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story.lead_photo.caption San Diego Padres second baseman Jake Cronenworth, left, gets the throw late as Houston Astros' Chas McCormick (20) is safe stealing second during the fourth inning of a baseball game Saturday, May 29, 2021, in Houston. (AP Photo/Michael Wyke)

HOUSTON — Fernando Tatis Jr. launched a monstrous, three-run homer with two outs in the ninth inning to tie it, Wil Myers hit a three-run drive in the 12th and the San Diego Padres beat the Houston Astros 11-8 on Saturday night.

A day after the Padres erupted for seven runs in the 11th inning, they played their fourth straight extra-inning game, going 3-1 in that span.

San Diego improved to an MLB-best 8-0 in interleague play this year. Houston has lost six of seven overall.

Myers had an RBI single to cap a two-run rally in the eighth that pulled the Padres within 6-3.

Astros reliever Ryan Pressly retired the first two batters in the ninth. But a walk to Manny Machado and a double by Jake Cronenworth brought up Tatis, who hit his 15th homer far over the left-field wall.

Tatis, who also homered Friday, had an RBI groundout in the sixth.

Myers connected against Ralph Garza Jr (0-1), sending a drive just over the glove of leaping right fielder Kyle Tucker for his fifth home run.

Miguel Daz pitched the 12th for his first career save.

Machado hit an RBI single in the 11th for an 8-7 lead, but Myles Straw scored on a wild pitch by Austin Adams (2-0) in the bottom half to tie the score.

After Eric Hosmer scored on a double play in the top of the 10th, Carlos Correa tied it at 7 with an RBI double. Correa also hit a two-run homer in the fourth.

Houston led 6-1 following a suicide squeeze by Garrett Stubbs in the sixth.

Jake Odorizzi permitted one run on three hits with four strikeouts in 5 1/3 innings. The right-hander, who retired 14 straight at one point, was making his first start since April 24 after going on the injured list with a strained muscle in his right arm.

Yu Darvish surrendered a season-high five runs - four earned — on four hits with five strikeouts and three walks in five innings.

Trainer's Room

Padres: CF Trent Grisham (bruised left foot) is hitting but not doing a lot of running or power shagging defensively yet, manager Jayce Tingler said. "He continues to progress with that foot, and we're pretty optimistic that if he continues to progress, he should be ready when the 10 days are up," Tingler said.

Astros: With Odorizzi coming off the injured list, Houston optioned RHP Enoli Paredes to Triple-A Sugar Land. 1B Yuli Gurriel was scratched from lineup with left middle finger inflammation. DH Yordan Alvarez missed a third straight game with a sore right wrist, but manager Dusty Baker said he is confident Alvarez will miss the IL. LHP Kent Emmanuel, who was placed on the IL on Friday with left elbow soreness, will get a second opinion on his elbow, Baker said.

UP NEXT

Astros RHP Zack Greinke (4-2, 3.97) will start Sunday against LHP Blake Snell (1-1, 4.50) in the finale of the three-game series.

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