The Chiefs have been hanging with the NFL elite almost since Andy Reid arrived as coach in 2013. For most of that period, the Browns were putrid.
As the first full weekend of the 2021 schedule gets going, Cleveland just might be the biggest threat to Kansas City making a third straight trip to the Super Bowl.
Yes, those Browns, who until Kevin Stefanski arrived and won top coaching honors last year were never in the conversation for the AFC title.
Now they are, probably deservedly after an 11-5 season, their first playoff appearance since 2002 and first postseason win since 1994. After winning at archrival Pittsburgh, the Browns tested the Chiefs before falling 22-17 in the divisional round.
To get past Reid, Patrick Mahomes and the Chiefs - on Sunday at Arrowhead Stadium and overall - would be yet another major achievement for Cleveland.
With the Chiefs seeking to equal the Dolphins, Bills and Patriots - yes, all AFC East teams - as the only clubs to reach three straight Super Bowls, Reid is cautious.
Pittsburgh at Buffalo
The other power in the AFC seems to be the Bills. If they keep protecting Josh Allen the way they have previously against the Steelers, they could be in business Sunday. The Steelers have topped the NFL in sacks each of the last four seasons but have gotten to Allen just twice in two meetings.
Pittsburgh opens on the road for the seventh straight season, having gone 3-2-1 in the past six. The Bills are 3-1 in season openers under coach Sean McDermott.
Green Bay vs. New Orleans
at Jacksonville, Florida
Sixteen years after Hurricane Katrina forced the Saints to play all their games away from New Orleans, they host the Packers at the Jaguars' home because of damage to the Big Easy from Hurricane Ida.
"I actually think the opposite is going to take place," says coach Sean Payton, referring to the entire team's relocation to a hotel with many family members in tow. "You're actually bringing a team a little closer together and it happens to come right at the start of the season ... I don't think it's something I look at in negative light."
Facing Aaron Rodgers, who won his third NFL MVP award last season, and a potent offense is quite a positive for the Saints, though.
Seattle at Indianapolis
If new QB Carson Wentz is recovered from a variety of setbacks, he'll make his Colts debut. But it's the Indianapolis defense that could decide this game.
Seattle, usually renowned for its hard-hitting defense, has a dangerous passing attack led by Russell Wilson throwing to DK Metcalf and Tyler Lockett. In 2020, Metcalf and Lockett became the second Seahawks receiving tandem to top 1,000 yards in the same season, and both are deep threats.
Los Angeles Chargers at Washington
Last season's top rookies, Chargers quarterback Justin Herbert and Washington edge defender Chase Young, will face off. That's a pretty juicy angle for a game in which Brandon Staley debuts as LA coach and Ryan Fitzpatrick starts at quarterback for his 32nd pro team. Well, his ninth.
The Chargers have 22 players new to the roster, including three free agent signings on the offensive line. Returning standouts edge rusher Joey Bosa and safety Derwin James on keys on defense.
Chicago at L.A. Rams
Rams coach Sean McVay certainly seems to be enjoying the addition of veteran Matthew Stafford as his quarterback.
"He has got such a great lens that he sees the game through and I've been able to learn a lot from him, as I know of some of our other coaches and his teammates," McVay says. "So, he has got such a great inventory of things to be able to draw on, and that's a really beneficial thing for our offense and especially for me."
The Bears often have faced Stafford from when he was with Detroit. This could be much less enjoyable for Chicago, which is 11-9 against him.
Baltimore at Las Vegas Monday night
Possibly the most damaging injury of the preseason was the torn-up knee for Ravens running back J.K. Dobbins. Baltimore relies so much on its ground game, so now Gus Edwards and quarterback Lamar Jackson, a resourceful runner, will see more duty.
The Raiders finally get to experience a home crowd just off the Vegas Strip. Time to show something entertaining: They are 19-29 in Jon Gruden's second stint in charge.
N.Y. Jets at Carolina
While there's more to this matchup than former Jets quarterback Sam Darnold facing them, and the rookie who has replaced him, Zach Wilson, getting his NFL indoctrination, those seem the best reasons to pay attention.
Carolina, despite injuries to key players including star RB Christian McCaffrey, showed spirit and spunk in 2020 under first-year coach Matt Rhule. New York displayed none of that in a 2-14 season under Adam Gase, and now Robert Saleh takes over the team with the longest postseason drought, since 2011.
Miami at New England
Whichever of these teams, if either, becomes a challenge to the new king of the AFC East, the Bills, it needs to win this one. With the focus on the two most recent Alabama quarterbacks, New England rookie Mac Jones and Miami's second-year player Tua Tagovailoa, the real key probably lies on the other side of the ball.
Brian Flores was one of the masterminds of the Patriots' D before becoming head coach in Miami, and New England added some key pieces to an already strong unit.
Minnesota at Cincinnati
The vibes out of Minnesota have not exactly been positive this summer. Coach Mike Zimmer made that clear regarding the vaccination topic.
"Maybe if some leaders miss games because of it and we end up losing games because of it, that might" change attitudes about getting vaccinated, he said. "Guys that are leaders of your team and they don't play and you lose the game, that might. Hopefully we don't have to find that out."
Cincinnati needs to find out how fit QB Joe Burrow is following his knee surgery that cost him the second half of the 2020 schedule. He played all of one series in preseason.
Arizona at Tennessee
2020 Offensive Player of the Year Derrick Henry's quest for the NFL rushing record held by Eric Dickerson begins against a defense that added J.J. Watt. Remember, Henry has an extra game this season to chase that mark of 2,105 yards in 1984; he rushed for 2,027.
Arizona could be one of the league's most exciting outfits with Kyler Murray running and throwing to the likes of DeAndre Hopkins, while Watt tries to recapture the form that took him to three Defensive Player of the Year awards.
Denver at N.Y. Giants
There's plenty of enthusiasm in Denver with Von Miller returning from injury to bolster a pretty good defense. The Broncos also have a solid corps of receivers for veteran QB Teddy Bridgewater, and their early schedule has the Giants, Jaguars and Jets. Time to make strides.
New York hopes third-year quarterback Daniel Jones makes major strides, and the Giants brought in a No. 1 wideout in Kenny Golladay. They also get back outstanding running back Saquon Barkley, though his recovery from last season's knee injury has been slow enough that he could miss this match.
Philadelphia at Atlanta
One of two matchups with first-year head coaches, the Eagles' Nick Sirianni and the Falcons' Arthur Smith. Neither had held the top job at any level of their coaching careers.
Philly was destroyed by injuries in finishing last in the weak NFC East and Atlanta couldn't stop anybody in 2020. Sirianni and Smith were offensive coordinators a year ago, in Indianapolis and Tennessee, with both teams making the playoffs.
Jacksonville at Houston
Two other new head men, with entirely different resumes. Urban Meyer, a huge success on the college level despite his wanderlust, is rebuilding the Jaguars, starting with top overall draft pick QB Trevor Lawrence.
David Culley, the only Black man hired for seven opening for head coaches this year, is a career assistant with 43 years of total coaching experience. He takes over perhaps the least-talented roster in the league.